REST Validated sgRNA vector

Name: REST Validated sgRNA vector
SKU: SKO0740
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : SKO0740

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Product Information

Vector Map

Gene Information

Cat. No.	SKO0740
Description	Creative Biogene develops and optimizes genome editing technology to produce stable genome edited mammalian cell lines serving a wide-range of R&D activities in areas of basic research, diagnostic and therapeutic development. Our premade SuperKO sgRNA vectors are tailor-made to target many different genes respectively. We have successfully constructed a series of knockout cell lines using those sgRNAs.
Gene Abbr	REST
Reporter	mCherry
Promoter	U6
Resistance	Amp
Selection	Ampicillin
Vector Type	Lentiviral Expression
Vector Length	7677 bp

Target Gene

REST

Background

This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]

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