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XIAP


Official Full Name
X-linked inhibitor of apoptosis
Organism
Homo sapiens
Gene ID
331
Background
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011]
Synonyms
API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3

Cat.No. Product Name Price
SHH447752 shRNA set against Rat XIAP (NM_022231.2) Inquiry
SHH447748 shRNA set against Mouse XIAP (NM_009688.2) Inquiry
SHW005100 shRNA set against Chicken XIAP (NM_204588) Inquiry
SHW015632 shRNA set against Danio rerio XIAP (NM_194396) Inquiry
Cat.No. Product Name Price
CDCB166575 Chicken XIAP ORF Clone (NM_204588) Inquiry
CDCB177107 Danio rerio XIAP ORF Clone (NM_194396) Inquiry
CDCL186789 Mouse XIAP ORF clone(NM_009688.2) Inquiry
CDFR011916 Rat Xiap cDNA Clone(NM_022231.2) Inquiry
MiUTR1M-02212 XIAP miRNA 3'UTR clone Inquiry
MiUTR1R-00568 XIAP miRNA 3'UTR clone Inquiry
SKO0113 XIAP Validated sgRNA vector Inquiry
CDCB195153 Rabbit XIAP ORF clone (XM_008273042.1) Inquiry
CDCR378919 Rat Xiap ORF Clone(NM_022231.2) Inquiry
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