Panoply™ Human WRN Knockdown Stable Cell Line

Name: Panoply™ Human WRN Knockdown Stable Cell Line
SKU: CSC-DC017533
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-DC017533

Host Cell : HEK293 (Hela and other cell types are also available) Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-DC017533
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Target Gene	WRN
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid Nitrogen
Shipping	Dry Ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	WRN Werner syndrome, RecQ helicase-like [ Homo sapiens ]
Gene Symbol	WRN
Synonyms	RECQ3; RECQL2; RECQL3
GeneID	7486
Uni ProtID	Q14191
mRNA Refseq	NM_000553.4
Protein Refseq	NP_000544.2
Chromosome Location	8p12
Function	3-5 DNA helicase activity; 3-5 exonuclease activity; ATP binding; ATP-dependent 3-5 DNA helicase activity; ATP-dependent DNA helicase activity; ATPase activity; DNA binding; DNA helicase activity; DNA helicase activity; G-quadruplex DNA binding; Y-form DNA binding; bubble DNA binding; exonuclease activity; four-way junction helicase activity; helicase activity; magnesium ion binding; manganese ion binding; protein binding; protein complex binding; protein homodimerization activity;
Pathway	Integrated Pancreatic Cancer Pathway, organism-specific biosystem; Regulation of Telomerase, organism-specific biosystem;
MIM	604611

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