Mouse Wrn ORF clone (NM_001122822.1)

Name: Mouse Wrn ORF clone (NM_001122822.1)
SKU: CDCH101524
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCH101524

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Product Information

Gene Information

Cat. No.	CDCH101524
Description	Mus musculus Werner syndrome homolog (human) (Wrn), transcript variant 2, mRNA.
Product Type	ORF clone
Gene Abbr	Wrn
Species	Mouse
ORF Size	4206bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

WRN

Background

This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]

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