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WRN


Official Full Name
WRN RecQ like helicase
Organism
Homo sapiens
Gene ID
7486
Background
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
Synonyms
RECQ3; RECQL2; RECQL3

Cat.No. Product Name Price
SHH447452 shRNA set against Human WRN (NM_000553.4) Inquiry
SHH447456 shRNA set against Mouse WRN (NM_011721.4) Inquiry
SHW004390 shRNA set against Chicken WRN (NM_001282289) Inquiry
Cat.No. Product Name Price
CDCH101524 Mouse Wrn ORF clone (NM_001122822.1) Inquiry
MiUTR3H-06956 WRN miRNA 3'UTR clone Inquiry
CDCB165865 Chicken WRN ORF Clone (NM_001282289) Inquiry
CDCB192527 Rabbit WRN ORF clone (XM_008252230.1) Inquiry
CDCR251200 Mouse Wrn ORF Clone(NM_011721.4) Inquiry
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