PML Validated sgRNA vector

Name: PML Validated sgRNA vector
SKU: SKO0956
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : SKO0956

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Product Information

Vector Map

Gene Information

Cat. No.	SKO0956
Description	Creative Biogene develops and optimizes genome editing technology to produce stable genome edited mammalian cell lines serving a wide-range of R&D activities in areas of basic research, diagnostic and therapeutic development. Our premade SuperKO sgRNA vectors are tailor-made to target many different genes respectively. We have successfully constructed a series of knockout cell lines using those sgRNAs.
Gene Abbr	PML
Reporter	mCherry
Promoter	U6
Resistance	Amp
Selection	Ampicillin
Vector Type	Lentiviral Expression
Vector Length	7677 bp

Target Gene

PML

Background

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

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