Panoply™ Human PML Knockdown Stable Cell Line

Name: Panoply™ Human PML Knockdown Stable Cell Line
SKU: CSC-DC012004
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-DC012004

Host Cell : HEK293 (Hela and other cell types are also available) Validation : Real-Time RCR

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Cell Line Information

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Gene Information

Cat. No.	CSC-DC012004
Description	Creative Biogene's Knockdown Cell Lines are target specific shRNA lentivirus transduced cells. The percent knockdown levels range from 75-99% depending on the gene, as evaluated by Real-Time RCR. Cells are rigorously qualified and mycoplasma free.
Target Gene	PML
Host Cell	HEK293 (Hela and other cell types are also available)
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Quality Control	Negative for bacteria, yeast, fungi and mycoplasma.
Storage	Liquid Nitrogen
Shipping	Dry Ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	PML promyelocytic leukemia [ Homo sapiens ]
Gene Symbol	PML
Synonyms	MYL; RNF71; PP8675; TRIM19
Gene Description	promyelocytic leukemia
GeneID	5371
Uni ProtID	P29590
mRNA Refseq	NM_002675.3
Protein Refseq	NP_002666.1
Chromosome Location	15q22
Function	DNA binding; SMAD binding; SUMO binding; cobalt ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription coactivator activity; ubiquitin protein ligase binding; zinc ion binding; zinc ion binding;
Pathway	Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Cytokine Signaling in Immune system, organism-specific biosystem; DNA damage response, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem;
MIM	102578

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