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Mouse Med1 ORF clone (NM_134027.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCL131621

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Product Information

Gene Information

Cat. No. CDCL131621
Description Mus musculus mediator complex subunit 1 (Med1), transcript variant 2, mRNA.
Product Type ORF clone
Gene Abbr Med1
Species Mouse
ORF Size 1671bp
Format purified plasmid
Vector pDONR
Warning Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.
Target Gene MED1
Background The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. [provided by RefSeq, Jul 2008]
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