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Cat.No. : CSC-RO0228 Host Cell: CHO-K1
| Cat. No. | CSC-RO0228 |
| Description | This cell line is engineered to stably overexpress the monkey HAVCR2 in CHO-K1 cells. |
| Introduction | CHO-K1/HAVCR2 is clonally derived from CHO-K1 cell line and stably expresses monkey Hepatitis A virus cellular receptor 2 (HAVCR2). The expression of HAVCR2 in this cell line has been validated through flow cytometry. |
| Gene | HAVCR2 |
| Host Cell | CHO-K1 |
| Host Cell Species | Cricetulus griseus (Chinese hamster) |
| Stability | Validated for at least 10 passages |
| Application | 1. Studying the interactions between immune cells and cancer cells 2. Studying the mechanisms of resistance to immune checkpoint blockade 3. High-throughput screening 4. Drug target validation |
| Quality Control | Negative for bacteria, yeast, fungi and mycoplasma. |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
A: The cell line facilitates the study of HAVCR2's role in the innate immune response by providing a platform to investigate how HAVCR2 influences the recognition and response to viral pathogens. This can lead to a better understanding of the host's defense mechanisms and the development of new strategies to enhance or modulate these responses.
A: The cell line can contribute to personalized medicine by helping researchers understand the variability in HAVCR2 expression and function among individuals. This knowledge can be used to develop targeted therapies that take into account individual genetic and molecular profiles, leading to more effective treatments for viral infections.
A: The cell line can be used in co-immunoprecipitation experiments, immunofluorescence assays, and other techniques to investigate the protein-protein interactions involving HAVCR2. This can help elucidate the complex network of interactions that regulate immune responses.
A: The cell line can be used to model the cellular responses to HAVCR2, which is often targeted by viruses to evade the host's immune system. By studying the HAVCR2 signaling pathway in this context, scientists can better understand the molecular mechanisms underlying immune evasion and develop targeted therapies to enhance antiviral immunity.
A: The cell line can be employed in high-throughput screening assays to identify compounds that modulate HAVCR2 activity. By testing the effects of various compounds on HAVCR2 signaling pathways, researchers can identify potential drug candidates that could be used to treat diseases associated with HAVCR2 dysfunction.
A: The unique advantage of the Monkey HAVCR2 Stable Cell Line - CHO-K1 is that it allows researchers to study HAVCR2 signaling in a cellular context that is more physiologically relevant than transient transfection systems. This cell line can be used to analyze the downstream effects of HAVCR2 activation on cellular processes, such as immune response and cell signaling.
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