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Human NBS1 Knockdown Cell Line-HeLa

Cat.No.
CSC-RK0011
Abbr
HeLa-HuNBS1 Knockdown
Alias
NBN,nibrin,AT V1,AT V2,ATV,NBS,P95,NBS1,
Growth Properties
Adherent
Host Cell
HeLa
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

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