Human NBN Knockdown Cell Line - Glioma

Name: Human NBN Knockdown Cell Line - Glioma
SKU: CSC-RK0247
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0247

Host Cell : Glioma Validation : Real-Time RCR

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Cell Line Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RK0247
Description	This cell line is engineered to stably express shRNA targeting human NBN.
Target Gene	NBN
Host Cell	Glioma
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Storage	Liquid nitrogen
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	NBN nibrin [ Homo sapiens ]
Gene Symbol	NBN
Synonyms	ATV; NBS; P95; NBS1; AT-V1; AT-V2
Gene Description	nibrin
Gene ID	4683
Uni Prot ID	O60934
m RNA Refseq	NM_002485.4
Protein Refseq	NP_002476.2
Chromosome Location	8q21
Function	contributes_to ATP-dependent DNA helicase activity; contributes_to damaged DNA binding; protein N-terminus binding; protein binding; transcription factor binding;
Pathway	ATM mediated phosphorylation of repair proteins, organism-specific biosystem; ATM mediated response to DNA double-strand break, organism-specific biosystem; Assembly of the RAD50-MRE11-NBS1 complex at DNA double-strand breaks, organism-specific biosystem; BARD1 signaling events, organism-specific biosystem; BRCA1-associated genome surveillance complex (BASC), organism-specific biosystem; DNA Repair, organism-specific biosystem; DNA damage response, organism-specific biosystem;
MIM	602667

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