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Human NBN Knockdown Cell Line-LN428 Glioma

Cat.No.
CSC-RK0247
Abbr
LN428 Glioma-HuNBN Knockdown
Alias
NBN,nibrin,AT V1,AT V2,ATV,NBS,P95,NBS1,AT-V1,AT-V2,FLJ10155,MGC87362,
Growth Properties
Adherent
Host Cell
LN428 glioma
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.

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