Human MUTYH adenoviral particles

Name: Human MUTYH adenoviral particles
SKU: AD10356Z
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : AD10356Z

Storage : -80℃ Shipping : Frozen on dry ice

Titer: Size:

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Virus Particles Information

Quality Control

Gene Information

Cat. No.	AD10356Z
Description	Adenovirus with ORF of mutY homolog (E. coli) (MUTYH), transcript variant gamma3.
Gene	MUTYH
Species	Human
Titer	Varies lot by lot, for example, ≥1x10^10 IFU/mL, ≥1x10^11 IFU/mL, ≥1x10^11 VP/mL etc.
Size	Varies lot by lot, for example, 100 ul, 500 ul, 1 mL etc.
Storage	Store at -80℃. Avoid multiple freeze/thaw cycles.
Shipping	Frozen on dry ice

Summary	Creative Biogene ensures high-quality adenovirus particles by optimizing and standardizing production protocols and performing stringent quality control (QC). The specific QC experiments performed vary between adenovirus particle lots.
Endotoxin	Endotoxins, primarily derived from Gram-negative bacteria, can trigger adverse immune responses. Endotoxin contamination is a significant concern in adenovirus production, especially for applications in animal studies and gene therapy. Creative Biogene utilizes rigorous endotoxin detection methods to monitor the endotoxin level in our produced adenovirus particles to ensure regulatory compliance.
Sterility	Creative Biogene ensures that adenovirus products are free of any bacterial, fungal and other microbial contamination.
Ad5 E1 Detection	All Creative Biogene adenoviruses are PCR tested to ensure that there are no detectable E1 sequences in the particles, which could be from revertants or external E1 contamination.
RCA Assays	Adenovirus products originating at Creative Biogene are guaranteed to have undetectable replication-competent adenovirus (RCA). This quality control measure is important because there is always the possibility of wild-type contamination due to revertants or environmental sources.
PFU Titering	All purified adenovirus preparations are tested for infectious titer. Creative Biogene's PFU test takes a few days longer but counts true plaques in HEK cells rather than estimating PFU titers via IHC staining or TCI50 of infected cells.

Gene Name	MUTYH mutY homolog (E. coli) [ Homo sapiens ]
Gene Symbol	MUTYH
Synonyms	MYH; CYP2C
Gene Description	mutY homolog (E. coli)
Gene ID	4595
Uni Prot ID	E5KP28
m RNA Refseq	NM_001048172.1
Protein Refseq	NP_001041637.1
Chromosome Location	1p34.1
Function	4 iron, 4 sulfur cluster binding; NOT MutLalpha complex binding; NOT MutLbeta complex binding; MutSalpha complex binding; NOT MutSbeta complex binding; endonuclease activity; hydrolase activity, acting on glycosyl bonds; metal ion binding; protein binding;
Pathway	Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Base-Excision Repair, AP Site Formation, organism-specific biosystem; Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystem; Cleavage of the damaged purine, organism-specific biosystem; DNA Repair, organism-specific biosystem;
MIM	604933

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