Human MUTYH Knockdown Cell Line - Glioma

Name: Human MUTYH Knockdown Cell Line - Glioma
SKU: CSC-RK0221
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CSC-RK0221

Host Cell : Glioma Validation : Real-Time RCR

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Cell Line Information

Safety and Packaging

Gene Information

Cat. No.	CSC-RK0221
Description	This cell line is engineered to stably express shRNA targeting human MUTYH.
Target Gene	MUTYH
Host Cell	Glioma
Host Cell Species	Homo sapiens (Human)
Applications	(1) Studying gene functions (2) Studying gene interactions and signaling pathways (3) Target validation and drug discovery (4) Designing diseases models
Size	>1 × 10⁶ cells / vial
Stability	Validated for at least 10 passages
Validation	Real-Time RCR
Storage	Liquid nitrogen
Shipping	Dry ice

Mycoplasma	Negative
Format	One frozen vial containing millions of cells
Storage	Liquid nitrogen
Safety Considerations	The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach.
Ship	Dry ice

Gene Name	MUTYH mutY homolog (E. coli) [ Homo sapiens ]
Gene Symbol	MUTYH
Synonyms	MYH; CYP2C
Gene Description	mutY homolog (E. coli)
Gene ID	4595
Uni Prot ID	E5KP28
m RNA Refseq	NM_001048172.1
Protein Refseq	NP_001041637.1
Chromosome Location	1p34.1
Function	4 iron, 4 sulfur cluster binding; NOT MutLalpha complex binding; NOT MutLbeta complex binding; MutSalpha complex binding; NOT MutSbeta complex binding; endonuclease activity; hydrolase activity, acting on glycosyl bonds; metal ion binding; protein binding;
Pathway	Base Excision Repair, organism-specific biosystem; Base excision repair, organism-specific biosystem; Base excision repair, conserved biosystem; Base-Excision Repair, AP Site Formation, organism-specific biosystem; Base-free sugar-phosphate removal via the single-nucleotide replacement pathway, organism-specific biosystem; Cleavage of the damaged purine, organism-specific biosystem; DNA Repair, organism-specific biosystem;
MIM	604933

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