Human DYRK1A adenoviral particles

DYRK1A (Dual Specificity Tyrosine-Regulated Kinase 1A) is a highly conserved gene located on human chromosome 21 that plays a key role in neural development, cell proliferation, and synaptic plasticity. As a member of the DYRK kinase family, it phosphorylates serine/threonine and tyrosine residues, affecting multiple cellular pathways. DYRK1A is particularly associated with Down syndrome, where its overexpression due to trisomy 21 leads to cognitive impairment and developmental delay. In addition, DYRK1A dysregulation has been associated with autism spectrum disorders (ASD) and Alzheimer's disease. The gene's functions range from regulation of transcription factors such as NFAT (nuclear factor of activated T cells) to regulation of the cell cycle and apoptosis, making it a key target for therapeutic research. Human DYRK1A adenoviral particles are genetically engineered viral vectors designed to deliver the DYRK1A gene or its variants to target cells for functional studies or therapeutic applications. Adenoviruses are favored for their high transduction efficiency, broad tropism, and ability to infect both dividing and non-dividing cells. These particles typically carry human DYRK1A sequences under the control of a strong promoter, allowing for stable expression in mammalian cells. Researchers use these tools to study the role of DYRK1A in disease mechanisms, screen for potential inhibitors, or explore gene therapy strategies for diseases such as Down syndrome or neurodegenerative disorders.