Rat Dyrk1a ORF Clone(NM_012791.2)

Name: Rat Dyrk1a ORF Clone(NM_012791.2)
SKU: CDCR377651
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR377651

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Product Information

Gene Information

Cat. No.	CDCR377651
Product Type	ORF Clone
Gene Abbr	Dyrk1a
Species	Rat
Tag	C-terminal Myc-DDK
ORF Size	2292 bp
Vector	pCMV6-Entry

Target Gene

DYRK1A

Background

This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008]

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