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shRNA set against Rat F2 (NM_053808.1)

For research use only. Not intended for any clinical use.

Cat. No. :   SHH288437

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Gene Information

Cat. No. SHH288437
Description The SureSilencing trade; shRNA Plasmids are designed to specifically knock down the expression of individual genes by RNA interference under either transient (with GFP) or stable transfection (for hygromycin, neomycin or puromycin-resistance) conditions after performance of the appropriate enrichment or selection procedures, respectively. Each vector contains the shRNA under control of the U1 promoter and either the GFP gene, for the enrichment of transiently transfected cells, or the neomycin or puromycin resistance genes, for the selection of stably transfected cells.
Gene Abbr F2
Gene Name F2 coagulation factor II [ Mus musculus ]
Species Rat
Report Gene GFP
Storage The SureSilencing shRNA Plasmids are shipped on dry ice or cold packs. Store all tubes at -20°C.
Gene Name F2 coagulation factor II [ Mus musculus ]
Gene Symbol F2
Synonyms Cf2; FII; Cf-2; thrombin
GeneID 14061
Uni ProtID P19221
mRNA Refseq NM_010168.2
Protein Refseq NP_034298.1
Chromosome Location 2 E1; 2 47.5 cM
Function calcium ion binding; catalytic activity; hydrolase activity; peptidase activity; protein binding; receptor binding; serine-type endopeptidase activity; serine-type endopeptidase activity; serine-type peptidase activity; thrombospondin receptor activity;
Pathway Blood Clotting Cascade, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; Diabetes pathways, organism-specific biosystem; Disease, organism-specific biosystem; Formation of Fibrin Clot (Clotting Cascade), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Gamma-carboxylation of protein precursors, organism-specific biosystem; Gamma-carboxylation, transport, and amino-terminal cleavage of proteins, organism-specific biosystem; Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem; Hemostasis, organism-specific biosystem; Intrinsic Pathway, organism-specific biosystem; Metabolism of proteins, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem; PTM: gamma carboxylation, hypusine formation and arylsulfatase activation, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Platelet Aggregation (Plug Formation), organism-specific biosystem; Platelet activation, signaling and aggregation, organism-specific biosystem; Post-translational protein modification, organism-specific biosystem; Regulation of Actin Cytoskeleton, organism-specific biosystem; Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs), organism-specific biosystem; Regulation of actin cytoskeleton, organism-specific biosystem; Regulation of actin cytoskeleton, conserved biosystem; Removal of aminoterminal propeptides from gamma-carboxylated proteins, organism-specific biosystem; Signal Transduction, organism-specific biosystem; Signaling by GPCR, organism-specific biosystem; Thrombin signalling through proteinase activated receptors (PARs), organism-specific biosystem; Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus, organism-specific biosystem;
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