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Cat. No. : RP00105 Tag : C-6His
Expressed Region : Glu39-Gly151 Expression System : Human Cell
| Cat. No. | RP00105 |
| Description | The Recombinant Human ROR1 (Ig-like domain, C-6His) is produced in our Human Cell expression system. The amino acid region expressed is Glu39-Gly151 with a 6His tag at the C terminus. |
| Species | Human |
| Tag | C-6His |
| Mol Weight | 13.4 KDa |
| Format | Powder |
| Expressed Region | Glu39-Gly151 |
| Expression System | Human Cell |
| Formulation | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| Purity |
>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS. |
| Endotoxin Level | < 1 EU/µg of protein by LAL method |
| Storage | Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles. |
| Shipping | The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below. |
| Reconstitution | Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
| Target Gene | ROR1 |
| Background | This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| Synonyms | Inactive tyrosine-protein kinase transmembrane receptor ROR1; Neurotrophic tyrosine kinase, receptor-related 1; ROR1; NTRKR1 |
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