Recombinant Human PCSK9 (D374Y,C-6His)

Name: Recombinant Human PCSK9 (D374Y,C-6His)
SKU: RP00137
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00137 Tag : C-6His

Expressed Region : Gln31-Gln692 (Asp374Tyr,Val474Ile, Gly504Arg, Gly670Glu) Expression System : Human Cell

Inquire for Price

Product Information

Gene Information

Cat. No.	RP00137
Description	The Recombinant Human PCSK9 (D374Y,C-6His) is produced in our Human Cell expression system. The amino acid region expressed is Gln31-Gln692 (Asp374Tyr,Val474Ile, Gly504Arg, Gly670Glu) with a 6His tag at the C terminus.
Species	Human
Tag	C-6His
Mol Weight	15-18&60-80 KDa
Conjugate	Unconjugated
Format	Liquid
Expressed Region	Gln31-Gln692 (Asp374Tyr,Val474Ile, Gly504Arg, Gly670Glu)
Expression System	Human Cell
Formulation	Supplied as a 0.2 μm filtered solution of 50mM HEPES, 150mM NaCl, 20% Glycerol, pH 7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.

Target Gene	PCSK9
Synonyms	Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1

Quick Inquiry

Background

Q & A

Customer Reviews

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.

Ask a Question

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

Question *

Name

Country *

Email *

Write a Review

Write a review of your use of Biogene products and services in your research. Your review can help your fellow researchers make informed purchasing decisions.

Product Name *

Catalog Name *

Rating

Needs improvement

Satisfaction

General satisfaction

Very satisfaction

Product Review Title *

Summary *