Recombinant Human PCSK9 (C-6His)

Name: Recombinant Human PCSK9 (C-6His)
SKU: RP00042

Cat.No. : RP00042 Tag: C-6His

Expressed Region: Gln31-Gln692 (Val474Ile, Gly670Glu) Expression System: Human Cell

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Product Details

Target Information

Cat. No.	RP00042
Description	The Recombinant Human PCSK9 (C-6His) is produced in our Human Cell expression system. The amino acid region expressed is Gln31-Gln692 (Val474Ile, Gly670Glu) with a 6His tag at the C terminus.
Species	Human
Tag	C-6His
Mol. Weight	13.77&58.2 KDa
Expressed Region	Gln31-Gln692 (Val474Ile, Gly670Glu)
Expression System	Human Cell
Format	Liquid
Formulation	Supplied as a 0.2 μm filtered solution of 20mM NaH₂PO₄, 150mM NaCl, 0.1M Arginine, 0.1M Glu, 0.01% Tween20, pH 7.4.
Conjugate	Unconjugated
Endotoxin Level	< 1 EU/µg of protein by LAL method
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.

Target Gene	PCSK9
Background	This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.
Synonyms	Proprotein Convertase Subtilisin/Kexin Type 9; Neural Apoptosis-Regulated Convertase 1; NARC-1; Proprotein Convertase 9; PC9; Subtilisin/Kexin-Like Protease PC9; PCSK9; NARC1

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