Recombinant Human L1CAM (C-Fc)

Name: Recombinant Human L1CAM (C-Fc)
SKU: RP00650
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00650 Tag : C-Fc

Expressed Region : Phe25-Glu698 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00650
Description	Recombinant Human L1CAM (C-Fc) is produced in our Human Cell expression system. The amino acid region expressed is Phe25-Glu698 with a Fc tag at the C terminus.
Species	Human
Tag	C-Fc
Mol Weight	101.2 kDa
Conjugate	Unconjugated
Format	Powder
Expressed Region	Phe25-Glu698
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	L1CAM
Synonyms	Vascular Cell Adhesion Protein 1; V-CAM 1; VCAM-1; INCAM-100; CD106; VCAM1; L1CAM

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The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons.

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