Recombinant Human HGF (C-Fc)

Name: Recombinant Human HGF (C-Fc)
SKU: RP00669
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00669 Tag : C-Fc

Expressed Region : Gln32-Ser728 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00669
Description	The Recombinant Human HGF (C-Fc) is produced in our Human Cell expression system. The amino acid region expressed is Gln32-Ser728 with a Fc tag at the C terminus.
Species	Human
Tag	C-Fc
Mol Weight	105~120 kDa, on SDS-PAGE under reducing conditions.
Format	Powder
Expressed Region	Gln32-Ser728
Expression System	Human Cell
Formulation	Lyophilized after extensive dialysis against PBS.
Purity	> 95% as analyzed by SDS-PAGE
Endotoxin Level	< 0.2 EU/μg of protein by gel clotting method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene

HGF

Synonyms

Hepatocyte Growth Factor (HGF),also known as hepatopoietin-A and scatter factor, is a pleiotropic mitogen belonging to the peptidase S1 family (plasminogen subfamily). It is produced by mesenchymal cells and acts on epithelial cells, endothelial cells and haemopoietic progenitor cells. HGF binds to the proto-oncogenic c-Met receptor to activate a tyrosine kinase signaling cascade. It regulates cell growth, motility and morphogenesis, thus it plays a pivotal role in angiogenesis, tumorogenesis and tissue regeneration.

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Background

Q & A

Customer Reviews

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss.

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