Recombinant Human CD46 (C-6His)

Name: Recombinant Human CD46 (C-6His)
SKU: RP00259
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00259 Tag : C-6His

Expressed Region : Cys35-Asp328 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00259
Description	The Recombinant Human CD46 (C-6His) is produced in our Human Cell expression system. The amino acid region expressed is Cys35-Asp328 with a 6His tag at the C terminus.
Species	Human
Tag	C-6His
Mol Weight	33.83 KDa
Conjugate	Unconjugated
Format	Powder
Expressed Region	Cys35-Asp328
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	CD46
Synonyms	Membrane Cofactor Protein; TLX; Trophoblast Leukocyte Common Antigen; CD46; MCP; MIC10

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The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

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