Recombinant Cynomolgus IL-2RA (C-6His)

Name: Recombinant Cynomolgus IL-2RA (C-6His)
SKU: RP00367
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00367 Tag : C-6His

Expressed Region : Glu22-Arg213 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00367
Description	The Recombinant Cynomolgus IL-2RA (C-6His) is produced in our Human Cell expression system. The amino acid region expressed is Glu22-Arg213 with a 6His tag at the C terminus.
Species	Cynomolgus
Tag	C-6His
Mol Weight	22.5 KDa
Format	Powder
Expressed Region	Glu22-Arg213
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	IL2RA
Synonyms	Interleukin-2 receptor subunit alpha; CD25; p55; TAC antigen; IL2-RA;IL-2R subunit alpha; IL-2-RA; IL-2 receptor subunit alpha

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The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk.

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