Recombinant Cynomolgus HAVCR2 (C-Fc)

Name: Recombinant Cynomolgus HAVCR2 (C-Fc)
SKU: RP00522
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : RP00522 Tag : C-Fc

Expressed Region : Ser22-Arg201 Expression System : Human Cell

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Product Information

Gene Information

Cat. No.	RP00522
Description	Recombinant Cynomolgus HAVCR2 (C-Fc) is produced in our Human Cell expression system. The amino acid region expressed is Ser22-Arg201 with a Fc tag at the C terminus.
Species	Cynomolgus
Tag	C-Fc
Mol Weight	46.3 KDa
Conjugate	Unconjugated
Format	Powder
Expressed Region	Ser22-Arg201
Expression System	Human Cell
Formulation	Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Purity	>95% as determined by SDS-PAGE. >90% as determined by SEC-MALS.
Endotoxin Level	< 1 EU/µg of protein by LAL method
Storage	Upon receipt, this product is stable for up to 6 months at temperatures below -70°C. Once reconstituted, the product is stable for up to 1 week at 4°C and up to 3 months at -20°C. Please avoid repeated freeze-thaw cycles.
Shipping	The product is shipped with ice packs. Upon receipt, store it immediately at the temperature recommended below.
Reconstitution	Always centrifuge tubes before opening. It is recommended to reconstitute the solution to a concentration above 100 μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Target Gene	HAVCR2
Background	The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
Synonyms	T cell immunoglobulin and mucin domain3; HAVCR2; Tim-3; TIM3

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