ITGB3 Easy KO Kit (Human)

Name: ITGB3 Easy KO Kit (Human)
SKU: CC-717
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CC-717

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Product Information

Gene Information

Cat. No.	CC-717
Description	A complete kit for efficient gene knockout in mammalian cells, combining chemically synthesized sgRNAs with Cas9 RNPs to induce targeted DNA cleavage and generate frameshift mutations or deletions. All essential reagents for transfection and knockout validation are included for rapid, high-efficiency gene disruption.
Gene Abbr	Itgb3
Gene Name	ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) [ Homo sapiens ]
Species	Human
EnsemblID	ENSMUSG00000020689
NCBIGeneID	16416
Uni ProtID	O54890
Features	All-in-One workflow from gene editing to knockout validation for users with no prior experience. Pre-validated sgRNAs and primers for rapid setup. Streamlined experiment handling. CRISPR RNP method ensures precise and efficient gene knockout.
Applications	This kit enables in vitro gene knockout in human-derived cells using chemically synthesized sgRNAs and Cas9-gRNA RNP complexes. Transfected RNPs cleave early exons of the target gene, inducing deletions or frameshift mutations for efficient and rapid knockout.
Reactions	5–10 reactions per target gene
Kit Components	2–3 chemically synthesized sgRNAs (200pmol each) 3 PCR/Sequencing primers (500pmol each) LM cell lysate (500µL) Cas9 protein (12µg) LM RNP transfection reagent (50µL)
Storage	Store at -80°C for up to 1 year or at -20°C for up to 6 months. Avoid repeated freeze-thaw cycles.

Gene Name	ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) [ Homo sapiens ]
Gene Symbol	ITGB3
Synonyms	GT; CD61; GP3A; BDPLT2; GPIIIa
Gene Description	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
GeneID	3690
Uni ProtID	P05106
mRNA Refseq	NM_000212.2
Protein Refseq	NP_000203.2
Chromosome Location	17q21.32
Function	cell adhesion molecule binding; identical protein binding; platelet-derived growth factor receptor binding; protein binding; protein disulfide isomerase activity; receptor activity; vascular endothelial growth factor receptor 2 binding; vascular endothelial growth factor receptor 2 binding;
Pathway	Arf6 signaling events, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy, organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Axon guidance, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Developmental Biology, organism-specific biosystem;
MIM	173470

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