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Cat.No. : CSC-RR01249 Host Cell: THP1
| Cat. No. | CSC-RR01249 |
| Description | THP1-GAS-Luc cell line is engineered to express luciferase reporter gene under the control of GAS (IFN‑γ‑activated sequence). It is a useful cell model for studying the GAF/GAS signaling pathway in THP1 cells. |
| Gene | GAS-Luc |
| Host Cell | THP1 |
| Host Cell Species | Homo sapiens (Human) |
| Stability | This cell line is stable at least 10 passages. |
| Product Type | Signaling Pathway Reporter Cell Lines |
| Applications | Utilized to measure GAS (gamma-interferon-activated sequence)-mediated signaling, primarily reflecting STAT1/3 activation; useful for investigating immune responses, cytokine effects, or drugs targeting STAT pathways. |
| Size Form | One vial of frozen cells, typically >1x10^6cells/vial |
| Shipping | Dry ice |
| Storage | Liquid nitrogen |
| Revival | Rapidly thaw cells in a 37°C water bath. Transfer contents into a tube containing pre-warmed media. Centrifuge cells and seed into a 25 cm2 flask containing pre-warmed media. |
| Growth Properties | Suspension cell line |
| Mycoplasma | Negative |
| Format | One frozen vial containing millions of cells |
| Storage | Liquid nitrogen |
| Safety Considerations |
The following safety precautions should be observed. 1. Use pipette aids to prevent ingestion and keep aerosols down to a minimum. 2. No eating, drinking or smoking while handling the stable line. 3. Wash hands after handling the stable line and before leaving the lab. 4. Decontaminate work surface with disinfectant or 70% ethanol before and after working with stable cells. 5. All waste should be considered hazardous. 6. Dispose of all liquid waste after each experiment and treat with bleach. |
| Ship | Dry ice |
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Creative Biogene’s GAS-Luc reporter line has been integral to our macrophage activation studies. The cells are specific to IFN-gamma stimulation with very little cross-reactivity. The stability of the transgene integration is impressive, providing consistent results across different batches of experiments.
Germany
02/13/2021
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