Mouse B2m Knockout Cell Line-Hepa1-6

The beta-2-microglobulin (B2m) gene encodes a component of the class I major histocompatibility complex (MHC I) molecule, which is present in all nucleated cells. B2m is located on chromosome 15 in humans and plays a key role in the immune system, particularly in the presentation of peptide antigens to T cells. One of the main functions of B2m is to stabilize the tertiary structure of MHC class I molecules, thereby ensuring their proper expression on the cell surface. Without this stabilization, MHC class I molecules are misfolded and cannot be effectively transported to the cell surface. This results in decreased immune surveillance and increased susceptibility to viral infections and cancer. Mutations or deletions in the B2m gene have been associated with various diseases. For example, a deficiency in B2m causes heavy chain deposition disease (HCDD), a type of amyloidosis in which monoclonal immunoglobulin heavy chains are deposited in tissues, leading to organ dysfunction. In addition, the absence of functional B2m impairs the presentation of endogenous antigens, making it easier for pathogens such as viruses and certain cancers to evade immunity. In addition to its role in the immune system, B2m has been studied as a potential biomarker for a variety of diseases. Elevated levels of B2m in serum or urine may indicate renal dysfunction, chronic inflammation, or lymphoproliferative disorders.