Human TGFBR3 mRNA

Name: Human TGFBR3 mRNA
SKU: PMRN-0253
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : PMRN-0253

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Product Information

Cat. No.	PMRN-0253
Description	The TGFBR3 mRNA encodes the human transforming growth factor beta receptor 3 (TGFBR3) protein, a transforming growth factor (TGF)-beta type III receptor. TGFBR3 is a membrane proteoglycan that often functions as a co-receptor with other TGF-beta receptor superfamily members. Ectodomain shedding produces soluble TGFBR3, which may inhibit TGFB signaling. Decreased expression of this receptor has been observed in various cancers.
Gene Type	Other
RNA Type	mRNA
Gene Name	TGFBR3
Species	Homo sapiens (Human)
Alias	BGCAN, betaglycan
Features	• mRNA synthesized on error free sequence verified plasmid DNA template • 100% replacement of UTP with modified nucleotides 5-Methoxy-UTP • Cap 1 Capping and poly-A tailed incorporated • Degrades the DNA template after RNA synthesis with DNase
Sequence	MTSHYVIAIF ALMSSCLATA GPEPGALCEL SPVSASHPVQ ALMESFTVLS GCASRGTTGL PQEVHVLNLR TAGQGPGQLQ REVTLHLNPI SSVHIHHKSV VFLLNSPHPL VWHLKTERLA TGVSRLFLVS EGSVVQFSSA NFSLTAETEE RNFPHGNEHL LNWARKEYGA VTSFTELKIA RNIYIKVGED QVFPPKCNIG KNFLSLNYLA EYLQPKAAEG CVMSSQPQNE EVHIIELITP NSNPYSAFQV DITIDIRPSQ EDLEVVKNLI LILKCKKSVN WVIKSFDVKG SLKIIAPNSI GFGKESERSM TMTKSIRDDI PSTQGNLVKW ALDNGYSPIT SYTMAPVANR FHLRLENNAE EMGDEEVHTI PPELRILLDP GALPALQNPP IRGGEGQNGG LPFPFPDISR RVWNEEGEDG LPRPKDPVIP SIQLFPGLRE PEEVQGSVDI ALSVKCDNEK MIVAVEKDSF QASGYSGMDV TLLDPTCKAK MNGTHFVLES PLNGCGTRPR WSALDGVVYY NSIVIQVPAL GDSSGWPDGY EDLESGDNGF PGDMDEGDAS LFTRPEIVVF NCSLQQVRNP SSFQEQPHGN ITFNMELYNT DLFLVPSQGV FSVPENGHVY VEVSVTKAEQ ELGFAIQTCF ISPYSNPDRM SHYTIIENIC PKDESVKFYS PKRVHFPIPQ ADMDKKRFSF VFKPVFNTSL LFLQCELTLC TKMEKHPQKL PKCVPPDEAC TSLDASIIWA MMQNKKTFTK PLAVIHHEAE SKEKGPSMKE PNPISPPIFH GLDTLTVMGI AFAAFVIGAL LTGALWYIYS HTGETAGRQQ VPTSPPASEN SSAAHSIGST QSTPCSSSST A
Storage	Store at or below -70°C. Avoid repeated freeze/thaw cycles. Aliquot if necessary using RNase-free equipment, reagents, pipet tips, tubes, and containers.

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Which protein does the Human TGFBR3 gene encode, and what functions do they all have?

A: TGFBR3 mRNA encodes human transforming growth factor-β receptor 3 (TGF-Br3) protein, which usually acts as a co-receptor together with other members of TGF-β receptor superfamily.

What is the role of Human TGFBR3 gene in the treatment of human cancer?

A: Many cancers, such as nonsyndromic cryptorchidism, have observed a decrease in the expression of this receptor, because this receptor is easy to shed from the outer domain to produce soluble TGFBR3, which may inhibit TGFB signal transduction.

What is the specific relationship between the deletion of TGFBR3 allele and the inheritance of primary human endometrial carcinoma?

A: LOH in Human TGFBR3 locus may be one of the mechanisms leading to the loss of β -sugar expression, so allele imbalance may be an early genetic element in the transformation of human endometrial tumors.

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