Human IL23A mRNA

Name: Human IL23A mRNA
SKU: PMRN-0161

For research use only. Not intended for any clinical use.

Cat.No.

PMRN-0161

Description

The IL23A mRNA encodes the human interleukin 23A (IL23A) protein, a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23A associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity.

Alias

P19; SGRF; IL-23; IL-23A; IL23P19

Features

• mRNA synthesized on error free sequence verified plasmid DNA template
• 100% replacement of UTP with modified nucleotides 5-Methoxy-UTP
• Cap 1 Capping and poly-A tailed incorporated
• Degrades the DNA template after RNA synthesis with DNase

Sequence

MLGSRAVMLL LLLPWTAQGR AVPGGSSPAW TQCQQLSQKL CTLAWSAHPL VGHMDLREEG DEETTNDVPH IQCGDGCDPQ GLRDNSQFCL QRIHQGLIFY EKLLGSDIFT GEPSLLPDSP VGQLHASLLG LSQLLQPEGH HWETQQIPSL SPSQPWQRLL LRFKILRSLQ AFVAVAARVF AHGAATLSP

Species

Homo sapiens (Human)

Storage

Store at or below -70°C. Avoid repeated freeze/thaw cycles. Aliquot if necessary using RNase-free equipment, reagents, pipet tips, tubes, and containers.

Publications

Q & A

Customer Reviews

Customer Q&As

What is Human IL23A mRNA?

A: Human IL23A mRNA is the messenger RNA of the human IL-23A gene. IL-23 is a cytokine that participates in immune and inflammatory responses.

What is the role of Human IL23A mRNA in the human body?

A: The function of Human IL23A mRNA is to encode the IL-23 protein. IL-23 can promote inflammatory and immune responses in the body, especially playing an important role in the occurrence and development of autoimmune diseases, inflammatory diseases, and tumors.

In which cells is Human IL23A mRNA expressed?

A: Human IL23A mRNA is mainly expressed in monocytes/macrophages, dendritic cells, and Th17 cells.

How is the expression of Human IL23A mRNA regulated?

A: The expression of Human IL23A mRNA is regulated by various factors, including gene transcription and post-transcriptional modifications. Some inflammatory factors, bacterial products, and immunostimulants can induce the expression of IL-23 gene. In addition, some transcription factors and signal transduction pathways can also affect the transcription of the IL-23 gene.

What diseases are associated with Human IL23A mRNA?

A: Research has shown that Human IL23A mRNA is associated with some inflammatory diseases, autoimmune diseases, and tumors, such as rheumatoid arthritis, psoriasis, inflammatory bowel disease, and certain types of cancer. In these diseases, the expression level of IL-23 may change, thereby affecting the progression and prognosis of the disease.

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