Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : PMRN-0254
| Cat. No. | PMRN-0254 |
| Description | The IFNAR1 mRNA encodes the human interferon alpha and beta receptor subunit 1 (IFNAR1) protein, a protein that belongs to the type II cytokine receptor family and functions as an antiviral factor. |
| Gene Type | Other |
| RNA Type | mRNA |
| Gene Name | IFNAR1 |
| Species | Homo sapiens (Human) |
| Alias | AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC |
| Features |
• mRNA synthesized on error free sequence verified plasmid DNA template • 100% replacement of UTP with modified nucleotides 5-Methoxy-UTP • Cap 1 Capping and poly-A tailed incorporated • Degrades the DNA template after RNA synthesis with DNase |
| Sequence | MMVVLLGATT LVLVAVAPWV LSAAAGGKNL KSPQKVEVDI IDDNFILRWN RSDESVGNVT FSFDYQKTGM DNWIKLSGCQ NITSTKCNFS SLKLNVYEEI KLRIRAEKEN TSSWYEVDSF TPFRKAQIGP PEVHLEAEDK AIVIHISPGT KDSVMWALDG LSFTYSLVIW KNSSGVEERI ENIYSRHKIY KLSPETTYCL KVKAALLTSW KIGVYSPVHC IKTTVENELP PPENIEVSVQ NQNYVLKWDY TYANMTFQVQ WLHAFLKRNP GNHLYKWKQI PDCENVKTTQ CVFPQNVFQK GIYLLRVQAS DGNNTSFWSE EIKFDTEIQA FLLPPVFNIR SLSDSFHIYI GAPKQSGNTP VIQDYPLIYE IIFWENTSNA ERKIIEKKTD VTVPNLKPLT VYCVKARAHT MDEKLNKSSV FSDAVCEKTK PGNTSKIWLI VGICIALFAL PFVIYAAKVF LRCINYVFFP SLKPSSSIDE YFSEQPLKNL LLSTSEEQIE KCFIIENIST IATVEETNQT DEDHKKYSSQ TSQDSGNYSN EDESESKTSE ELQQDFV |
| Storage | Store at or below -70°C. Avoid repeated freeze/thaw cycles. Aliquot if necessary using RNase-free equipment, reagents, pipet tips, tubes, and containers. |
A: The human protein encoded by IFNAR1 mRNA belongs to the type II cytokine receptor family and has antiviral functions.
A: Human type I IFNAR1 deficiency does not have a largely unaffected effect on SARS-CoV-2 mRNA vaccination. Based on results from the literature, RBD-specific IgG serum t was immunized by humoral immunity in all patients and the magnitude and duration of the response was largely unaffected by IFNAR1 deficiency.
A: The receptor for type I interferon has been studied to consist of two subunits, IFNAR1 and IFNAR2. IFNAR1 binding to type I IFN activates the JAK-STAT signaling pathway, which is essential for regulating growth, survival, differentiation, pathogen resistance and antiviral immunity.
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Currently, my own graduate work is related to genetic immunity, and I purchased IFNAR1 mRNA to see if I could do some modulation. After using it, I found a lot of expressed protein with few impurities and high purity, so I highly recommend it.
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