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Human FGF12 mRNA

For research use only. Not intended for any clinical use.
Cat.No.
PMRN-0072
Description
The FGF12 mRNA encodes the human fibroblast growth factor 12 (FGF12) protein, a member of the fibroblast growth factor (FGF) family. FGF12 probably involves in nervous system development and function, and the positive regulation of voltage-gated sodium channel activity.
Alias
DEE47, EIEE47, FGF12B, FHF1
Features
• mRNA synthesized on error free sequence verified plasmid DNA template
• 100% replacement of UTP with modified nucleotides 5-Methoxy-UTP
• Cap 1 Capping and poly-A tailed incorporated
• Degrades the DNA template after RNA synthesis with DNase
Sequence
MAAAIASSLI RQKRQARESN SDRVSASKRR SSPSKDGRSL CERHVLGVFS KVRFCSGRKR PVRRRPEPQL KGIVTRLFSQ QGYFLQMHPD GTIDGTKDEN SDYTLFNLIP VGLRVVAIQG VKASLYVAMN GEGYLYSSDV FTPECKFKES VFENYYVIYS STLYRQQESG RAWFLGLNKE GQIMKGNRVK KTKPSSHFVP KPIEVCMYRE PSLHEIGEKQ GRSRKSSGTP TMNGGKVVNQ DST
Species
Homo sapiens (Human)
Storage
Store at or below -70°C. Avoid repeated freeze/thaw cycles. Aliquot if necessary using RNase-free equipment, reagents, pipet tips, tubes, and containers.

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Q & A

Customer Reviews

Customer Q&As
What are the main proteins encoded by the FGF12 mRNA gene in the human body?

A: FGF12 mRNA encodes human fibroblast growth factor 12 (FGF12) protein, a member of the fibroblast growth factor (FGF) family.

What biological activities are human FGF12 mRNAs involved in?

A: FGF12 may be involved in the development and function of the nervous system and the positive regulation of voltage-gated sodium channel activity.

What are the diseases associated with the FGF12 gene?

A: Disorders associated with FGF12 include developmental and epileptic encephalopathy47 and nonspecific early-onset epileptic encephalopathy. Its related pathways include the apoptotic pathway and GPCR pathway in synovial fibroblasts.

What is the role of FGF21 in intracellular signaling?

A: Although FGF21 signaling can promote post-translational protein modifications60,61 and alter gene expression62,63, little is known about intracellular signaling pathways and intracellular FGF21 mechanisms of action.

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Customer Reviews
Easy to use

Covers a wide range of sensitivities. The work of b expression regulation assay of liver signal peptide using Human FGF12 mRNA does not require special instrumentation, just a follow the routine steps of injection experiment. This is your best choice when you have limited experimental conditions.

United States

03/28/2022

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