Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : PMRN-0205
| Cat. No. | PMRN-0205 |
| Description | The CXCR2 mRNA encodes the human C-X-C motif chemokine receptor 2 (CXCR2) protein, a member of the G-protein-coupled receptor family. CXCR2 is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. |
| Gene Type | Other |
| RNA Type | mRNA |
| Gene Name | CXCR2 |
| Species | Homo sapiens (Human) |
| Alias | CD182; IL8R2; IL8RA; IL8RB; CMKAR2; CDw128b |
| Features |
• mRNA synthesized on error free sequence verified plasmid DNA template • 100% replacement of UTP with modified nucleotides 5-Methoxy-UTP • Cap 1 Capping and poly-A tailed incorporated • Degrades the DNA template after RNA synthesis with DNase |
| Sequence | MEDFNMESDS FEDFWKGEDL SNYSYSSTLP PFLLDAAPCE PESLEINKYF VVIIYALVFL LSLLGNSLVM LVILYSRVGR SVTDVYLLNL ALADLLFALT LPIWAASKVN GWIFGTFLCK VVSLLKEVNF YSGILLLACI SVDRYLAIVH ATRTLTQKRY LVKFICLSIW GLSLLLALPV LLFRRTVYSS NVSPACYEDM GNNTANWRML LRILPQSFGF IVPLLIMLFC YGFTLRTLFK AHMGQKHRAM RVIFAVVLIF LLCWLPYNLV LLADTLMRTQ VIQETCERRN HIDRALDATE ILGILHSCLN PLIYAFIGQK FRHGLLKILA IHGLISKDSL PKDSRPSFVG SSSGHTSTTL |
| Storage | Store at or below -70°C. Avoid repeated freeze/thaw cycles. Aliquot if necessary using RNase-free equipment, reagents, pipet tips, tubes, and containers. |
A: The CXCR2 is a receptor for interleukin 8 (IL8) and binds to chemokine (C-X-C pattern) ligand 1 (CXCL1/MGSA), a protein with melanoma growth-stimulating activity that has been shown to be a major component required for serum-dependent melanoma cell growth.
A: CXCR2 (C-X-C motif chemokine receptor 2) is a protein-coding gene. Diseases associated with CXCR2 include cardioembolic syndrome and Cxcr2 deficiency due to autosomal recessive severe congenital granulocytopenia.
A: CXCR2 gene homologs: The CXCR2 gene is conserved in chimpanzees, rhesus monkeys, dogs, cattle, mice, rats, zebrafish and frogs. These reference sequences exist independently of genome construction.
A: CXCR2 expression on granulocytes and macrophage progenitors (GMP) was found to be involved in myeloid differentiation in the tumor environment.
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