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Human CXCL8 mRNA

For research use only. Not intended for any clinical use.
Cat.No.
PMRN-0146
Description
The IL8 mRNA encodes the human interleukin 8 (IL8) protein, a member of the CXC chemokine family. IL8 is a major mediator of the inflammatory response. It also functions as a chemotactic factor by guiding the neutrophils to the site of infection.
Alias
IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1; SCYB8
Features
• mRNA synthesized on error free sequence verified plasmid DNA template
• 100% replacement of UTP with modified nucleotides 5-Methoxy-UTP
• Cap 1 Capping and poly-A tailed incorporated
• Degrades the DNA template after RNA synthesis with DNase
Sequence
MTSKLAVALL AAFLISAALC EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS
Species
Homo sapiens (Human)
Storage
Store at or below -70°C. Avoid repeated freeze/thaw cycles. Aliquot if necessary using RNase-free equipment, reagents, pipet tips, tubes, and containers.

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Q & A

Customer Reviews

Customer Q&As
How to detect CXCL8 mRNA?

A: CXCL8 mRNA was demonstrated only in normal retina by RT-PCR, and receptor expression was confirmed by protein blotting and RT-PCR. The presence of CXCR1 and CXCR2, but not CXCL8, was detected by immunostaining in glial protofibrillary acidic protein-positive neuroglia of the cellular PVR membrane.

What is CXC sequential chemokine ligand 8?

A: Gene results for CXCL8 C-X-C motif chemokine ligand 8 show that the protein encoded by this gene is a member of the CXC chemokine family, a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8.

What are the effects when CXCL8 mRNA is secreted by tumor cells?

A: Secretion of this protein by tumor cells promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases vascular permeability, and elevated IL-8 levels are positively associated with increased severity of a variety of disease outcomes, such as sepsis.

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Customer Reviews
Rapid & Simple

Rapid and simple expression of interleukin-8.

France

11/03/2022

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