Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : PMRN-0146
| Cat. No. | PMRN-0146 |
| Description | The IL8 mRNA encodes the human interleukin 8 (IL8) protein, a member of the CXC chemokine family. IL8 is a major mediator of the inflammatory response. It also functions as a chemotactic factor by guiding the neutrophils to the site of infection. |
| Gene Type | Other |
| RNA Type | mRNA |
| Gene Name | CXCL8 |
| Species | Homo sapiens (Human) |
| Alias | IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1; SCYB8 |
| Features |
• mRNA synthesized on error free sequence verified plasmid DNA template • 100% replacement of UTP with modified nucleotides 5-Methoxy-UTP • Cap 1 Capping and poly-A tailed incorporated • Degrades the DNA template after RNA synthesis with DNase |
| Sequence | MTSKLAVALL AAFLISAALC EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS |
| Storage | Store at or below -70°C. Avoid repeated freeze/thaw cycles. Aliquot if necessary using RNase-free equipment, reagents, pipet tips, tubes, and containers. |
A: CXCL8 mRNA was demonstrated only in normal retina by RT-PCR, and receptor expression was confirmed by protein blotting and RT-PCR. The presence of CXCR1 and CXCR2, but not CXCL8, was detected by immunostaining in glial protofibrillary acidic protein-positive neuroglia of the cellular PVR membrane.
A: Gene results for CXCL8 C-X-C motif chemokine ligand 8 show that the protein encoded by this gene is a member of the CXC chemokine family, a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8.
A: Secretion of this protein by tumor cells promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases vascular permeability, and elevated IL-8 levels are positively associated with increased severity of a variety of disease outcomes, such as sepsis.
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Rapid and simple expression of interleukin-8.
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