Human BAK1 mRNA

Name: Human BAK1 mRNA
SKU: PMRN-0260

For research use only. Not intended for any clinical use.

Cat.No.

PMRN-0260

Description

The BAK1 mRNA encodes the human BCL2 antagonist/killer 1 (BAK1) protein, a member of the BCL2 protein family. BAK1 localizes to mitochondria, and functions to induce apoptosis. It also interacts with the tumor suppressor P53 after exposure to cell stress.

Alias

BAK, BAK-LIKE, BCL2L7, CDN1

Features

• mRNA synthesized on error free sequence verified plasmid DNA template
• 100% replacement of UTP with modified nucleotides 5-Methoxy-UTP
• Cap 1 Capping and poly-A tailed incorporated
• Degrades the DNA template after RNA synthesis with DNase

Sequence

MASGQGPGPP RQECGEPALP SASEEQVAQD TEEVFRSYVF YRHQQEQEAE GVAAPADPEM VTLPLQPSST MGQVGRQLAI IGDDINRRYD SEFQTMLQHL QPTAENAYEY FTKIATSLFE SGINWGRVVA LLGFGYRLAL HVYQHGLTGF LGQVTRFVVD FMLHHCIARW IAQRGGWVAA LNLGNGPILN VLVVLGVVLL GQFVVRRFFK S

Species

Homo sapiens (Human)

Storage

Store at or below -70°C. Avoid repeated freeze/thaw cycles. Aliquot if necessary using RNase-free equipment, reagents, pipet tips, tubes, and containers.

Publications

Q & A

Customer Reviews

Customer Q&As

What is BAK1 mRNA?

A: BAK1 mRNA is a messenger RNA molecule encoding BAK1, a member of the Bcl-2 family of anti-apoptotic proteins in human cells.

In which tissues is human BAK1 mRNA expressed?

A: It is expressed in many tissues, including liver, kidney, lung, heart, pancreas and intestine.

What is the function of BAK1 mRNA？

A: Human BAK1 mRNA encodes a protein, BAK1, that plays a key role in regulating apoptosis by promoting increased mitochondrial outer membrane permeability to induce apoptosis.

What diseases are mutations in the BAK1 gene associated with?

A: Mutations in the human BAK1 gene have been associated with a variety of diseases, including cancer, autoimmune diseases, and neurological disorders.

Can the BAK1 gene be used as a therapeutic target?

A: BAK1 mRNA encodes a protein, BAK1, that has been shown to be a potential target for the treatment of cancer, and a number of BAK1 inhibitors have been investigated in clinical trials.

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