DsRedExpress Reporter Cell Line - MC38

The MC38 adenocarcinoma colorectal cell line is a well-established and frequently used tumor model for preclinical research on neoantigens and immunotherapeutic approaches. This transplantable cell line was established in 1975 by repeatedly injecting mice with the carcinogen dimethylhydrazine and thus has the characteristics of tumors with a high mutational load. MC38 cells exhibit similar characteristics to human colon adenocarcinoma, making them valuable for studying this disease. They have an epithelial morphology and are capable of forming tumors when implanted in animal models. Researchers are using MC38 to study genetic alterations, signaling pathways, immune checkpoint regulation and drug sensitivity in colorectal cancer. It has been widely used to evaluate the efficacy of various treatments, including chemotherapy, immunotherapy, and combination therapies. DsRedExpress Reporter Cell Line - MC38 is a unique and innovatively developed research tool that is widely used in a variety of scientific research. This specially engineered cell line is derived from MC38 cells. The main feature that distinguishes this cell line is the stable expression of the DsRedExpress2 fluorescent protein. The reporter emits red fluorescence, allowing easy and precise detection and analysis of cells. Scientists frequently exploit this capability for in vivo imaging of tumors and other biological structures, as well as for tracking cell proliferation, migration, and protein expression in real time. In addition, unlike green fluorescent protein (GFP), the red fluorescence of DsRedExpress does not cause phototoxic effects, making it safer and less damaging to cells during experiments.