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Rat Tmprss2 cDNA Clone(NM_130424.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR013897

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Gene Information

Cat. No. CDFR013897
Description NativeORF clone of Rattus norvegicus transmembrane protease, serine 2 (Tmprss2) as transfection-ready DNA NM_130424.2
Product Type cDAN Clone
Gene Abbr Tmprss2
Species Rat
Vector pCMV6Entry
Target Gene TMPRSS2
Background This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]
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