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Rat Ptpn11 ORF Clone(NM_013088.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR377966

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Product Information

Gene Information

Cat. No. CDCR377966
Product Type ORF Clone
Gene Abbr Ptpn11
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1782 bp
Vector pCMV6-Entry
Target Gene PTPN11
Background The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016]
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