Transfected Stable Cell Lines
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Cat. No. : CDCR377966
| Cat. No. | CDCR377966 |
| Product Type | ORF Clone |
| Gene Abbr | Ptpn11 |
| Species | Rat |
| Tag | C-terminal Myc-DDK |
| ORF Size | 1782 bp |
| Vector | pCMV6-Entry |
| Target Gene | PTPN11 |
| Background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia. [provided by RefSeq, Aug 2016] |
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