Rat Prnp cDNA Clone(NM_012631.2)

Name: Rat Prnp cDNA Clone(NM_012631.2)
SKU: CDFR010449
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR010449

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Product Information

Gene Information

Cat. No.	CDFR010449
Description	NativeORF clone of Rattus norvegicus prion protein (Prnp) as transfection-ready DNA NM_012631.2
Product Type	cDAN Clone
Gene Abbr	Prnp
Species	Rat
Vector	pCMV6Entry

Target Gene

PRNP

Background

The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. An overlapping open reading frame has been found for this gene that encodes a smaller, structurally unrelated protein, AltPrp. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

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