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Rat Orc1 cDNA Clone(NM_177931.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR014901

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Gene Information

Cat. No. CDFR014901
Description NativeORF clone of Rattus norvegicus origin recognition complex, subunit 1-like (yeast) (Orc1l) as transfection-ready DNA NM_177931.2
Product Type cDAN Clone
Gene Abbr Orc1
Species Rat
Vector pCMV6Entry
Target Gene ORC1
Background The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
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