Mouse Orc1 ORF Clone(NM_011015.2)

Name: Mouse Orc1 ORF Clone(NM_011015.2)
SKU: CDCR249937
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCR249937

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Product Information

Gene Information

Cat. No.	CDCR249937
Product Type	ORF Clone
Gene Abbr	Orc1
Species	Mouse
Tag	C-terminal Myc-DDK
ORF Size	2522 bp
Size	10 ug
Vector	pCMV6-Entry

Target Gene

ORC1

Background

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

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