Rat Mbd2 cDNA Clone(NM_001115025.1)

Name: Rat Mbd2 cDNA Clone(NM_001115025.1)
SKU: CDFR009407
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR009407

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Product Information

Gene Information

Cat. No.	CDFR009407
Description	NativeORF clone of Rattus norvegicus methyl-CpG binding domain protein 2 (Mbd2) as transfection-ready DNA NM_001115025.1
Product Type	cDAN Clone
Gene Abbr	Mbd2
Species	Rat
Vector	pCMV6Entry

Target Gene

MBD2

Background

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

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