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Rat Loxl2 ORF Clone(NM_001106047.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR372849

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Gene Information

Cat. No. CDCR372849
Product Type ORF Clone
Gene Abbr Loxl2
Species Rat
Tag C-terminal Myc-DDK
ORF Size 2331 bp
Vector pCMV6-Entry
Target Gene LOXL2
Background This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. [provided by RefSeq, Jul 2008]
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