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Rat Lef1 ORF Clone(NM_130429.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR380936

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Product Information

Gene Information

Cat. No. CDCR380936
Product Type ORF Clone
Gene Abbr Lef1
Species Rat
Tag C-terminal Myc-DDK
ORF Size 1194 bp
Vector pCMV6-Entry
Target Gene LEF1
Background This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
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