Rat Krit1 cDNA Clone(NM_001108618.1)

Name: Rat Krit1 cDNA Clone(NM_001108618.1)
SKU: CDFR008209
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDFR008209

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Product Information

Gene Information

Cat. No.	CDFR008209
Description	NativeORF clone of Rattus norvegicus KRIT1, ankyrin repeat containing (Krit1) as transfection-ready DNA NM_001108618.1
Product Type	cDAN Clone
Gene Abbr	Krit1
Species	Rat
Vector	pCMV6Entry

Target Gene

KRIT1

Background

This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

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