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Mouse Krit1 ORF Clone(NM_001170552.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDCR241860

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Product Information

Gene Information

Cat. No. CDCR241860
Product Type ORF Clone
Gene Abbr Krit1
Species Mouse
Tag C-terminal TurboGFP
ORF Size 2094 bp
Size 10 ug
Vector pCMV6-AC-GFP
Target Gene KRIT1
Background This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
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