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Mouse Krit1 cDNA Clone(NM_001170552.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFG021178

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Product Information

Gene Information

Cat. No. CDFG021178
Product Type cDNA clone
Gene Abbr Krit1
Species Mouse
ORF Size 2094bp
Size 10 ug
Vector pCMV6Entry
Target Gene KRIT1
Background This gene encodes a protein containing four ankyrin repeats, a band 4.1/ezrin/radixin/moesin (FERM) domain, and multiple NPXY sequences. The encoded protein is localized in the nucleus and cytoplasm. It binds to integrin cytoplasmic domain-associated protein-1 alpha (ICAP1alpha), and plays a critical role in beta1-integrin-mediated cell proliferation. It associates with junction proteins and RAS-related protein 1A (Rap1A), which requires the encoded protein for maintaining the integrity of endothelial junctions. It is also a microtubule-associated protein and may play a role in microtubule targeting. Mutations in this gene result in cerebral cavernous malformations. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]
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