Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
Cat. No. : CDFR001326
| Cat. No. | CDFR001326 |
| Description | NativeORF clone of Rattus norvegicus itchy E3 ubiquitin protein ligase homolog (mouse) (Itch) as transfection-ready DNA NM_001005887.1 |
| Product Type | cDAN Clone |
| Gene Abbr | Itch |
| Species | Rat |
| Size | 10 ug |
| Vector | pCMV6Entry |
| Target Gene | ITCH |
| Background | This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012] |
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