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Rat Itch cDNA Clone(NM_001005887.1)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR001326

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Gene Information

Cat. No. CDFR001326
Description NativeORF clone of Rattus norvegicus itchy E3 ubiquitin protein ligase homolog (mouse) (Itch) as transfection-ready DNA NM_001005887.1
Product Type cDAN Clone
Gene Abbr Itch
Species Rat
Size 10 ug
Vector pCMV6Entry
Target Gene ITCH
Background This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
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