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Mouse Itch cDNA Clone(BC062934)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFG022265

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Gene Information

Cat. No. CDFG022265
Product Type cDNA clone
Gene Abbr Itch
Species Mouse
ORF Size 5163bp
Size 10 ug
Vector pCMV6-Kan/Neo
Target Gene ITCH
Background This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein plays a role in multiple cellular processes including erythroid and lymphoid cell differentiation and the regulation of immune responses. Mutations in this gene are a cause of syndromic multisystem autoimmune disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
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