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Rat Il1rn cDNA Clone(NM_022194.2)

For research use only. Not intended for any clinical use.

Cat. No. :   CDFR011881

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Gene Information

Cat. No. CDFR011881
Description NativeORF clone of Rattus norvegicus interleukin 1 receptor antagonist (Il1rn) as transfection-ready DNA NM_022194.2
Product Type cDAN Clone
Gene Abbr Il1rn
Species Rat
Vector pCMV6Entry
Target Gene IL1RN
Background The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]
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