Mouse Il1rn ORF clone (NM_001039701.3)

Name: Mouse Il1rn ORF clone (NM_001039701.3)
SKU: CDCL120421
Availability: InStock

For research use only. Not intended for any clinical use.

Cat. No. : CDCL120421

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Product Information

Gene Information

Cat. No.	CDCL120421
Description	Mus musculus interleukin 1 receptor antagonist (Il1rn), transcript variant 2, mRNA.
Product Type	ORF clone
Gene Abbr	Il1rn
Species	Mouse
ORF Size	537bp
Format	purified plasmid
Vector	pDONR
Warning	Please note that the protein for this clone has been annotated or predicted in the UNIPROT database to have a signal peptide. Placing a tag at the N-terminus of this protein may result in loss of the signal peptide function.

Target Gene

IL1RN

Background

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]

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